ALX Oncology (ALXO): A Rising Star in the US Stocks up in the pre-market

ALXO Stock

ALX Oncology, a clinical-stage immuno-oncology company’s stock has been on a surge in the premarket session today, making it a focal point for investors and market analysts alike.

In the pre-market session, the stock demonstrated exceptional performance, with its price skyrocketing to $9.96, reflecting an astonishing change of 107.06%.

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This dramatic surge in price was accompanied by substantial trading activity, as the trading volume reached a significant 10,620,000 shares.

Understanding ALX Oncology

ALX Oncology is a publicly traded company that focuses on developing therapies that block the CD47 immune checkpoint pathway.

This innovative approach is designed to bridge the innate and adaptive immune system, providing a new line of defense against cancer. The company’s lead product candidate, evorpacept, has shown promising clinical responses across a range of hematologic and solid malignancies.

Factors Influencing the Rise

The surge in ALX Oncology’s stock price can be attributed to several factors. Most notably, the company recently announced positive interim Phase 2 data from its ASPEN-06 clinical trial.

This trial is evaluating the effectiveness of evorpacept in combination with other treatments for patients with HER2-positive gastric/gastroesophageal junction (“GEJ”) cancer.

ASPEN-06 Clinical Trial: A Closer Look

The ASPEN-06 clinical trial is a randomized multi-center international study. It assesses the efficacy of evorpacept in combination with trastuzumab, CYRAMZA® (ramucirumab), and paclitaxel. The trial focuses on advanced HER2-positive gastric/GEJ cancer patients.

Interim Analysis Results

The interim analysis represents results from 54 randomized patients with second and third-line gastric/GEJ cancer. The report indicates that the confirmed overall response rate (ORR) for the evorpacept combination treatment was 52%, compared to 22% for the control group treatment.

The safety profile of evorpacept was consistent with previous clinical trials, and the drug was well-tolerated by patients. The interim results compare favorably to the efficacy reported for CYRAMZA with paclitaxel in the RAINBOW study, which is considered the global standard of care for second line gastric/GEJ cancer.

Expert Opinions on ALX Oncology’s Progress

The success of the ASPEN-06 clinical trial has been recognized by industry experts. Sophia Randolph, M.D., Ph.D., Chief Medical Officer at ALX Oncology, highlighted that the trial validates the potential of evorpacept both in solid tumors and in combination with anti-cancer antibodies.

ALX Oncology’s Future Plans

ALX Oncology has a roadmap for future development. The company plans to focus on combining evorpacept with anti-cancer antibodies, ADCs, and PD-1/PD-L1 immune checkpoint inhibitors. This approach aims to maximize the potential of evorpacept and further solidify the company’s position in the immuno-oncology sphere.


ALX Oncology’s stock continues to develop and refine its therapeutic options, it is poised to have a significant impact on the US stocks market and the broader field of immuno-oncology.

Investors, market analysts, and healthcare professionals alike will be keenly watching ALX Oncology’s continued progress. As the company moves forward with its clinical trials and research, it will undoubtedly remain a focal point in market news.

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